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9
Cat. No. | Product Name | Target | Signaling Pathways |
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T4008 |
Metergoline
甲麦角林,Methergoline,Liserdol |
Dopamine Receptor; 5-HT Receptor; Sodium Channel | GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience |
Metergoline (Methergoline) 是多巴胺激动剂和血清素拮抗剂。它是 h5-HT7受体的高亲和力配体,Ki 为 16 nM。它还是可逆神经 Na+通道抑制剂,用于研究季节性情绪障碍、催乳激素调节。 | |||
T7943 |
Fluphenazine decanoate
|
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Fluphenazine decanoate 是一种高度连续的多巴胺 D2受体阻滞剂,是一种长效吩噻嗪抗精神病药,用于精神分裂症的研究。 | |||
TP1937L1 |
RFRP-1 (human) acetate(311309-25-8 free base)
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
RFRP-1 (human) acetate(311309-25-8 free base) 是一种有效的内源性 NPFF 受体激动剂(NPFF2 和 NPFF1 的 EC50 值分别为 0.0011 和 29 nM)。它减弱离体大鼠和兔心肌细胞的收缩功能。降低心率、每搏输出量、射血分数和心输出量,并增加大鼠的血浆催乳素水平。 GnIH 同系物。 | |||
T24003 |
Disulergine
CM 29717,CH 29717,CH 29-717 |
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Disulergine is a dopamine receptor agonist. It also prolactin release-inhibiting 8 alpha-amino-ergoline. | |||
T75947 |
RFRP-1(human) TFA
|
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RFRP-1(human) TFA, an endogenous NPFF receptor agonist, exhibits potent activity with EC50 values of 0.0011 nM for NPFF2 and 29 nM for NPFF1. It significantly diminishes the contractile function of isolated rat and rabbit cardiac myocytes. Moreover, it decreases heart rate, stroke volume, ejection fraction, and cardiac output, while elevating plasma prolactin levels in rats. | |||
T68551 |
Cabergoline diphosphate
|
||
Cabergoline diphosphate is a dopamine D2 receptor agonist used for prolactinoma treatment. Cabergoline permits rapid and effective hormonal and tumor control by normalizing prolactin-producing pituitary adenomas levels. | |||
T8775 |
Lisuride maleate
R-(+)-LISURIDE HYDROGEN MALEATE |
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Lisuride maleate is an agonist of Dopamine receptor and anti-Parkinson's agent. Displays high affinity for D2, D3 and D4 receptors along with 5-HT1A. Exhibits some 5-HT2B receptor antagonist properties. Decreases prolactin release; reduces inflammatory me | |||
T81390 |
Prolactin-Releasing Peptide (1-31) (rat)
|
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Prolactin-Releasing Peptide (1-31) (rat) 通过减少禁食诱导的大鼠食物摄入,有效提升血浆LH、FSH及睾酮水平。 | |||
T81391 |
Prolactin-Releasing Peptide (12-31), rat
|
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Prolactin-Releasing Peptide (12-31), rat 为催乳素释放肽的一个段落,对 GPR10 受体具有高度亲和性,并能在转染了 PrRP 受体的 CHOK1 细胞中激发钙离子动员。 | |||
TP1937 |
RFRP-1(human)
RFRP-1 (human) |
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Potent endogenous NPFF receptor agonist (EC50 values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduces heart rate, stroke volume, ejection fraction and cardiac out | |||
T81598 |
Org OD 02-0
10-Ethenyl-19-norprogesterone |
p38 MAPK | MAPK |
Org OD 02-0(10-Ethenyl-19-norprogesterone)为mPRα(膜孕酮受体α)特异性激动剂,IC50值为33.9 nM。该化合物能够激活MAPK活性,并且能抑制催乳素(PRL)的分泌。 | |||
T83756 |
S1H TFA
Site 1-binding Helix |
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S1H是一种人造肽类模拟物,模仿人类生长激素的第36至51个氨基酸,且为生长激素受体的拮抗剂。在溶液中呈现α-螺旋结构,并在100和200纳摩尔(nM)的浓度下,能降低SK-MEL-28和MALME-3M黑色素瘤细胞系以及IM-9 B细胞淋巴细胞中,由人类生长激素及泌乳素诱导的STAT5磷酸化。 | |||
TP1532 |
γ-2-MSH (41-58), amide
|
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Melanocortin (MC) 3-MSH (Melanocyte-Stimulating Hormone) is believed to signal through the MC 3 receptor. It induces a sustained increase in intracellular free calcium levels ([Ca2+]i) in a subpopulation of pituitary cells. Most of the cells responding to |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T14853 |
Cabergoline
FCE-21336,卡麦角林 |
Dopamine Receptor; 5-HT Receptor; Autophagy | Autophagy; GPCR/G Protein; Neuroscience |
Cabergoline (FCE-21336) 是一种麦角衍生的多巴胺 D2亚类受体激动剂,高亲和力作用于D2、D3和5-HT2B 受体,Ki 分别为 0.7、1.5 和 1.2。 |
Cat. No. | Product Name | Species | Expression System |
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TMPY-01053 |
Prolactin Receptor Protein, Human, Recombinant (His)
hPRLrI,PRLR,MFAB,HPRL,prolactin receptor |
Human | HEK293 Cells |
Prolactin Receptor Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is P16471-1. | |||
TMPY-02434 |
Prolactin Receptor Protein, Rat, Recombinant (His)
prolactin receptor,RATPRLR,MGC105486 |
Rat | HEK293 Cells |
Prolactin Receptor Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is P05710-1. | |||
TMPY-02984 |
Prolactin Receptor Protein, Mouse, Recombinant (His)
Pr-1,Pr-3,AI987712,prolactin receptor,Prlr... |
Mouse | HEK293 Cells |
Prolactin Receptor Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is P07321. | |||
TMPY-01566 |
Prolactin Receptor Protein, Mouse, Recombinant (His & hFc)
prolactin receptor,Prlr,Pr-3,Pr-1,Prlr-rs1... |
Mouse | HEK293 Cells |
Prolactin Receptor Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 52.5 kDa and the accession number is Q08501-1. | |||
TMPJ-00347 |
PRLR Protein, Mouse, Recombinant (His)
PRLR,PRL-R,Prolactin receptor,Prolacti... |
Mouse | HEK293 Cells |
PRLR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 33-40 KDa and the accession number is Q08501. | |||
TMPJ-00346 |
PRLR Protein, Mouse, Recombinant (hFc)
Prolactin R,Prlr,Prolactin receptor |
Mouse | HEK293 Cells |
PRLR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 62-88 KDa and the accession number is Q08501. | |||
TMPK-00547 |
PRLR Protein, Cynomolgus, Recombinant (His)
Prolactin R,HPRL,MFAB,PRL-R |
Cynomolgus | HEK293 Cells |
Prolactin receptor (PRLR) is highly expressed in a subset of human breast cancer and prostate cancer, which makes it a potential target for cancer treatment. In clinical trials, the blockade of PRLR was shown to be safe but with poor efficacy. It is therefore urgent to develop new therapies against PRLR target. Bispecific antibodies (BsAbs) could guide immune cells toward tumor cells, and produced remarkable effects in some cancers. PRLR Protein, Cynomolgus, Recombinant (His) is expressed in HEK... | |||
TMPK-01375 |
PRLR Protein, Canine, Recombinant (hFc)
PRL-R,Prolactin R,MFAB,HPRL |
Canine | HEK293 Cells |
Prolactin receptor (PRLR) is highly expressed in a subset of human breast cancer and prostate cancer, which makes it a potential target for cancer treatment. In clinical trials, the blockade of PRLR was shown to be safe but with poor efficacy. It is therefore urgent to develop new therapies against PRLR target. Bispecific antibodies (BsAbs) could guide immune cells toward tumor cells, and produced remarkable effects in some cancers. PRLR Protein, Canine, Recombinant (hFc) is expressed in HEK293 ... | |||
TMPH-02274 |
JAK2 Protein, Human, Recombinant (His)
|
Human | E. coli |
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple int... |